Orbitrap™ Excedion™ Pro Mass Spectrometers

Enhance your research and achieve groundbreaking discoveries with Orbitrap Excedion Pro Hybrid Mass Spectrometers, with models to meet your specific needs. The Orbitrap Excedion Pro BioPharma Mass Spectrometer delivers extended capabilities for biopharma characterization applications and higher order structural biology with mass detection up to m/z 12,000. In addition, optional fast and sensitive Electron Transfer Dissociation (ETD) and Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) alternative fragmentation can be field or factory installed. The core model Orbitrap Excedion Pro Mass Spectrometer offers exceptional performance for proteomics with advanced capabilities for sensitive non-targeted metabolomics and lipidomics analysis. Optional fast and sensitive ETD/EThcD can be factory or field installed for proteomics applications.

Elevate your biopharma characterization

• Detect low abundant Asp/IsoAsp isomerization
• Detailed structural elucidation: Discern Leucin and Isoleucin isobaric masses with great confidence
• Top-up the sequence coverage in middle-down analysis with fast radical driven fragmentation

 

Innovate higher-order structure characterization of biomolecules

• ETD fragmentation option enables near single residue resolution in bottom-up and top-down Hydrogen-Deuterium Exchange (HDX) analysis with high sensitivity for alternative fragmentation ETD in ion routing multipole and combination of EThcD in the ion routing multipole for detection in the Orbitrap mass analyzer
• Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation
• HDX-based MS offers a comprehensive and novel toolset for the analysis of protein conformation, conformation dynamics, and protein-protein interactions

 

Exceed in proteomics research

• Accurate quantification with extended dynamic range
• Hybrid-DIA
• Deep proteome coverage
• PTMs analysis with ETD fragmentation
• Immunopeptidomics with EThcD fragmentation

 

Discovery in metabolomics research

• Increased sensitivity up to 10x compound dependent
• Enhanced Dynamic Range (eDR)
• Increased unknown annotations

 

Simultaneously measure multiple parameters within a single experiment

• Up to 20 precursor ions per scan